|Other Names||Sodium-dependent serotonin transporter, 5HT transporter, 5HTT, Solute carrier family 6 member 4, SLC6A4, HTT, SERT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin|
|Tissue Location||Expressed in platelets (at protein level).|
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This gene encodes an integral membrane protein thattransports the neurotransmitter serotonin from synaptic spaces intopresynaptic neurons. The encoded protein terminates the action ofserotonin and recycles it in a sodium-dependent manner. Thisprotein is a target of psychomotor stimulants, such as amphetaminesand cocaine, and is a member of the sodium:neurotransmittersymporter family. A repeat length polymorphism in the promoter ofthis gene has been shown to affect the rate of serotonin uptake andmay play a role in sudden infant death syndrome, aggressivebehavior in Alzheimer disease patients, anddepression-susceptibility in people experiencing emotional trauma.
Blaya, C., et al. Neurosci. Lett. 485(1):11-15(2010)Schillani, G., et al. Anticancer Res. 30(9):3823-3826(2010)Muhonen, L.H., et al. Psychiatry Res (2010) In press :Jijun, L., et al. Neurol India 58(4):523-529(2010)Devlin, A.M., et al. PLoS ONE 5 (8), E12201 (2010) :
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