|Other Names||Sodium-dependent serotonin transporter, 5HT transporter, 5HTT, Solute carrier family 6 member 4, SLC6A4, HTT, SERT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin|
|Tissue Location||Expressed in platelets (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an integral membrane protein thattransports the neurotransmitter serotonin from synaptic spaces intopresynaptic neurons. The encoded protein terminates the action ofserotonin and recycles it in a sodium-dependent manner. Thisprotein is a target of psychomotor stimulants, such as amphetaminesand cocaine, and is a member of the sodium:neurotransmittersymporter family. A repeat length polymorphism in the promoter ofthis gene has been shown to affect the rate of serotonin uptake andmay play a role in sudden infant death syndrome, aggressivebehavior in Alzheimer disease patients, anddepression-susceptibility in people experiencing emotional trauma.
Blaya, C., et al. Neurosci. Lett. 485(1):11-15(2010)Schillani, G., et al. Anticancer Res. 30(9):3823-3826(2010)Muhonen, L.H., et al. Psychiatry Res (2010) In press :Jijun, L., et al. Neurol India 58(4):523-529(2010)Devlin, A.M., et al. PLoS ONE 5 (8), E12201 (2010) :
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