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POMT2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UKY4 |
|---|---|
| Clone Names | 100712143 |
| Gene ID | 29954 |
|---|---|
| Other Names | Protein O-mannosyl-transferase 2, Dolichyl-phosphate-mannose--protein mannosyltransferase 2, POMT2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | POMT2 |
|---|---|
| Function | Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient (PubMed:14699049, PubMed:28512129). Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins (PubMed:28512129). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in testis; detected at low levels in most tissues |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is anO-mannosyltransferase that requires interaction with the product ofthe POMT1 gene for enzymatic function. The encoded protein is foundin the membrane of the endoplasmic reticulum. Defects in this geneare a cause of Walker-Warburg syndrome (WWS).
References
Manya, H., et al. J. Biochem. 147(3):337-344(2010)Yanagisawa, A., et al. Eur J Med Genet 52(4):201-206(2009)Murakami, T., et al. Brain Dev. 31(6):465-468(2009)Mercuri, E., et al. Neurology 72(21):1802-1809(2009)Messina, S., et al. Neuromuscul. Disord. 18(7):565-571(2008)
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