|Other Names||Protein O-mannosyl-transferase 2, Dolichyl-phosphate-mannose--protein mannosyltransferase 2, POMT2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient.|
|Cellular Location||Endoplasmic reticulum membrane; Multi- pass membrane protein|
|Tissue Location||Highly expressed in testis; detected at low levels in most tissues|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is anO-mannosyltransferase that requires interaction with the product ofthe POMT1 gene for enzymatic function. The encoded protein is foundin the membrane of the endoplasmic reticulum. Defects in this geneare a cause of Walker-Warburg syndrome (WWS).
Manya, H., et al. J. Biochem. 147(3):337-344(2010)Yanagisawa, A., et al. Eur J Med Genet 52(4):201-206(2009)Murakami, T., et al. Brain Dev. 31(6):465-468(2009)Mercuri, E., et al. Neurology 72(21):1802-1809(2009)Messina, S., et al. Neuromuscul. Disord. 18(7):565-571(2008)
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