|Other Names||Neuronal acetylcholine receptor subunit alpha-6, CHRNA6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an alpha subunit of neuronal nicotinicacetylcholine receptors. These receptors consist of five subunitsand function as ion channels involved in neurotransmission. Theencoded protein is a subunit of neuronal nicotinic acetylcholinereceptors that mediate dopaminergic neurotransmission and areactivated by acetylcholine and exogenous nicotine. Alternativelyspliced transcript variants have been observed for this gene.Single nucleotide polymorphisms in this gene have been associatedwith both nicotine and alcohol dependence.
Saccone, N.L., et al. Genes Brain Behav. 9(7):741-750(2010)Hoft, N.R., et al. Genes Brain Behav. (2010) In press :Thorgeirsson, T.E., et al. Nat. Genet. 42(5):448-453(2010)Rigbi, A., et al. Pharmacogenomics J. (2010) In press :Zeiger, J.S., et al. Hum. Mol. Genet. 17(5):724-734(2008)
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