|Other Names||E3 ubiquitin-protein ligase MARCH9, 632-, Membrane-associated RING finger protein 9, Membrane-associated RING-CH protein IX, MARCH-IX, RING finger protein 179, MARCH9, RNF179|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.|
|Cellular Location||Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitously expressed.|
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MARCH9 is a member of the MARCH family of membrane-boundE3 ubiquitin ligases (EC 184.108.40.206). MARCH enzymes add ubiquitin(see MIM 191339) to target lysines in substrate proteins, therebysignaling their vesicular transport between membrane compartments.MARCH9 induces internalization of several membrane glycoproteinsand directs them to the endosomal compartment (Bartee et al., 2004[PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]).[suppliedby OMIM].
Nice, T.J., et al. J. Immunol. 185(9):5369-5376(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Hoer, S., et al. FEBS Lett. 581(1):45-51(2007)Bartee, E., et al. J. Virol. 78(3):1109-1120(2004)
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