|Other Names||Methylcytosine dioxygenase TET2, 11411n2, TET2, KIAA1546|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5- formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.|
|Tissue Location||Broadly expressed. Highly expressed in hematopoietic cells; highest expression observed in granulocytes Expression is reduced in granulocytes from peripheral blood of patients affected by myelodysplastic syndromes|
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Provided below are standard protocols that you may find useful for product applications.
TET2 may catalyze the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC) (By similarity). Play an important role in the regulation of myelopoiesis.
Mallo, M., et al. Haematologica 95(10):1798-1800(2010)Smith, A.E., et al. Blood (2010) In press :Tefferi, A., et al. Leukemia 24(7):1302-1309(2010)Kim, S.T., et al. Prostate (2010) In press :Rocquain, J., et al. BMC Cancer 10, 401 (2010) :
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