|Other Names||Neuroepithelial cell-transforming gene 1 protein, Proto-oncogene p65 Net1, Rho guanine nucleotide exchange factor 8, NET1, ARHGEF8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Widely expressed.|
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NET1 acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway (By similarity).
Lee, J., et al. J. Biol. Chem. 285(34):26618-26627(2010)Carr, H.S., et al. J. Biol. Chem. 284(36):24269-24280(2009)Gilcrease, M.Z., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):80-86(2009)Murray, D., et al. Br. J. Cancer 99(8):1322-1329(2008)Guerra, L., et al. PLoS ONE 3 (5), E2254 (2008) :
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