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NET1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q7Z628 |
|---|---|
| Clone Names | 100528101 |
| Gene ID | 10276 |
|---|---|
| Other Names | Neuroepithelial cell-transforming gene 1 protein, Proto-oncogene p65 Net1, Rho guanine nucleotide exchange factor 8, NET1, ARHGEF8 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NET1 |
|---|---|
| Synonyms | ARHGEF8 |
| Function | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. |
| Cellular Location | Cytoplasm. Nucleus. |
| Tissue Location | Widely expressed.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
NET1 acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway (By similarity).
References
Lee, J., et al. J. Biol. Chem. 285(34):26618-26627(2010)Carr, H.S., et al. J. Biol. Chem. 284(36):24269-24280(2009)Gilcrease, M.Z., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):80-86(2009)Murray, D., et al. Br. J. Cancer 99(8):1322-1329(2008)Guerra, L., et al. PLoS ONE 3 (5), E2254 (2008) :
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