|Other Names||Neuroepithelial cell-transforming gene 1 protein, Proto-oncogene p65 Net1, Rho guanine nucleotide exchange factor 8, NET1, ARHGEF8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
NET1 acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway (By similarity).
Lee, J., et al. J. Biol. Chem. 285(34):26618-26627(2010)Carr, H.S., et al. J. Biol. Chem. 284(36):24269-24280(2009)Gilcrease, M.Z., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):80-86(2009)Murray, D., et al. Br. J. Cancer 99(8):1322-1329(2008)Guerra, L., et al. PLoS ONE 3 (5), E2254 (2008) :
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