|Other Names||Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide, hDAPP1, B lymphocyte adapter protein Bam32, B-cell adapter molecule of 32 kDa, DAPP1, BAM32|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May act as a B-cell-associated adapter that regulates B- cell antigen receptor (BCR)-signaling downstream of PI3K.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation|
|Tissue Location||Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells.|
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Provided below are standard protocols that you may find useful for product applications.
DAPP1 may act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.
Manna, D., et al. J. Biol. Chem. 282(44):32093-32105(2007)Niiro, H., et al. J. Immunol. 173(9):5601-5609(2004)Allam, A., et al. J. Biol. Chem. 279(38):39775-39782(2004)Han, A., et al. Immunity 19(4):621-632(2003)Marshall, A.J., et al. Mol. Cell. Biol. 22(15):5479-5491(2002)
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