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C9orf7 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UGQ2 |
|---|---|
| Clone Names | 100406199 |
| Gene ID | 11094 |
|---|---|
| Other Names | Calcium channel flower homolog, Calcium channel flower domain-containing protein 1, CACFD1, C9orf7 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CACFD1 |
|---|---|
| Synonyms | C9orf7 |
| Function | Transmembrane protein which mediates synaptic endocytosis and fitness-based cell culling (PubMed:31341286, PubMed:37348560). In response to different stimulus strengths, controls two major modes of synaptic vesicle (SV) retrieval in hippocampal neurons; Clathrin- mediated endocytosis (CME) in response to mild stimulation and activity-dependent bulk endocytosis (ADBE) in response to strong stimulation (By similarity). In cytotoxic T-lymphoocytes (CTLs) facilitates calcium-dependent endocytosis of cytotoxic granules at the immuno synapse (By similarity). Different isoforms work as fitness fingerprints in 'loser' and 'winner' cells and thereby mediate win/lose decisions as part of the cell competition process (PubMed:31341286). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:D4A9I3}. Golgi apparatus {ECO:0000250|UniProtKB:D4A9I3}. Vesicle {ECO:0000250|UniProtKB:Q8BG21} Note=In cytotoxic T-lymphoocytes, localizes to intracellular vesicles that move to the immuno synapse (By similarity). Enriched in synaptic vesicles at the presynpatic vesicles (By similarity). Detected in the Golgi apparatus of cultured hippocampal neurons (By similarity) {ECO:0000250|UniProtKB:D4A9I3, ECO:0000250|UniProtKB:Q8BG21} [Isoform 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Detected in skin cells at low levels of expression (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
C9orf7 belongs to the calcium channel flower family.
References
Yao, C.K., et al. Cell 138(5):947-960(2009)Yuan, X., et al. Am. J. Hum. Genet. 83(4):520-528(2008)Humphray, S.J., et al. Nature 429(6990):369-374(2004)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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