|Other Names||Sclerostin, SOST|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level)|
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Sclerostin is a secreted glycoprotein with a C-terminalcysteine knot-like (CTCK) domain and sequence similarity to the DAN(differential screening-selected gene aberrative in neuroblastoma)family of bone morphogenetic protein (BMP) antagonists.Loss-of-function mutations in this gene are associated with anautosomal-recessive disorder, sclerosteosis, which causesprogressive bone overgrowth. A deletion downstream of this gene,which causes reduced sclerostin expression, is associated with amilder form of the disorder called van Buchem disease. [provided byRefSeq].
van Lierop, A.H., et al. Eur. J. Endocrinol. 163(5):833-837(2010)Liu, J.M., et al. J. Clin. Endocrinol. Metab. 95 (9), E112-E120 (2010) :Paternoster, L., et al. J. Clin. Endocrinol. Metab. 95(8):3940-3948(2010)Piters, E., et al. Hum. Mutat. 31 (7), E1526-E1543 (2010) :Collette, N.M., et al. Dev. Biol. 342(2):169-179(2010)
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