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SOST Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9BQB4
Clone Names 100617094
Additional Information
Gene ID 50964
Other Names Sclerostin, SOST
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOST (HGNC:13771)
Function Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level).
Research Areas
Citations (0)
citation

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Background

Sclerostin is a secreted glycoprotein with a C-terminalcysteine knot-like (CTCK) domain and sequence similarity to the DAN(differential screening-selected gene aberrative in neuroblastoma)family of bone morphogenetic protein (BMP) antagonists.Loss-of-function mutations in this gene are associated with anautosomal-recessive disorder, sclerosteosis, which causesprogressive bone overgrowth. A deletion downstream of this gene,which causes reduced sclerostin expression, is associated with amilder form of the disorder called van Buchem disease. [provided byRefSeq].

References

van Lierop, A.H., et al. Eur. J. Endocrinol. 163(5):833-837(2010)Liu, J.M., et al. J. Clin. Endocrinol. Metab. 95 (9), E112-E120 (2010) :Paternoster, L., et al. J. Clin. Endocrinol. Metab. 95(8):3940-3948(2010)Piters, E., et al. Hum. Mutat. 31 (7), E1526-E1543 (2010) :Collette, N.M., et al. Dev. Biol. 342(2):169-179(2010)

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$ 277.78
Cat# BP17391a
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