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CD68/CD68 (kpi) Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P34810
Clone Names 101229076
Peptide ID 101229076
Additional Information
Gene ID 968
Other Names Macrosialin, Gp110, CD68, CD68
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD68
Function Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Cellular Location Isoform Short: Cell membrane; Single-pass type I membrane protein
Tissue Location Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites
Research Areas
Citations (0)

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This gene encodes a 110-kD transmembrane glycoprotein thatis highly expressed by human monocytes and tissue macrophages. Itis a member of the lysosomal/endosomal-associated membraneglycoprotein (LAMP) family. The protein primarily localizes tolysosomes and endosomes with a smaller fraction circulating to thecell surface. It is a type I integral membrane protein with aheavily glycosylated extracellular domain and binds to tissue- andorgan-specific lectins or selectins. The protein is also a memberof the scavenger receptor family. Scavenger receptors typicallyfunction to clear cellular debris, promote phagocytosis, andmediate the recruitment and activation of macrophages. Alternativesplicing results in multiple transcripts encoding differentisoforms.


Leonarduzzi, G., et al. Mol Nutr Food Res 54 SUPPL 1, S31-S41 (2010) :Strojnik, T., et al. Anticancer Res. 29(8):3269-3279(2009)Sayed, S., et al. Eur J Vasc Endovasc Surg 38(1):20-25(2009)Suzuki, Y., et al. Int J Rheum Dis 12(1):7-13(2009)Chen, W.S., et al. Scand. J. Rheumatol. 38(2):154-155(2009)

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$ 80.00
Cat# BP17393c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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