|Other Names||Sclerostin domain-containing protein 1, Ectodermal BMP inhibitor, Ectodin, Uterine sensitization-associated gene 1 protein, USAG-1, SOSTDC1, USAG1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.|
|Tissue Location||Highly expressed in kidney and weakly in lung.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the sclerostin family and encodesan N-glycosylated, secreted protein with a C-terminal cystineknot-like domain. This protein functions as a bone morphogeneticprotein (BMP) antagonist. Specifically, it directly associates withBMPs, prohibiting them from binding their receptors, therebyregulating BMP signaling during cellular proliferation,differentiation, and programmed cell death.
Barber, M.J., et al. PLoS ONE 5 (3), E9763 (2010) :Ohshima, J., et al. Genes Chromosomes Cancer 48(12):1037-1050(2009)Blish, K.R., et al. Mol. Biol. Cell 19(2):457-464(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Yanagita, M. Cytokine Growth Factor Rev. 16(3):309-317(2005)
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