|Other Names||Platelet-activating factor acetylhydrolase 2, cytoplasmic, Serine-dependent phospholipase A2, SD-PLA2, hSD-PLA2, PAFAH2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme.|
|Tissue Location||Broadly expressed in different tissues, but high in B- and T-lymphocytes. In brain, expression is restricted to amygdala and frontal cortex|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes platelet-activating factoracetylhydrolase isoform 2, a single-subunit intracellular enzymethat catalyzes the removal of the acetyl group at the SN-2 positionof platelet-activating factor (identified as1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, thislipase exhibits a broader substrate specificity than simplyplatelet activating factor. Two other isoforms of intracellularplatelet-activating factor acetylhydrolase exist, and both aremulti-subunit enzymes. Additionally, there is a single-subunitserum isoform of this enzyme.
Schmidt, E.B., et al. Atherosclerosis 196(1):420-424(2008)Umemura, K., et al. Stroke 38(3):1063-1068(2007)Unno, N., et al. J. Surg. Res. 134(1):36-43(2006)Marques, M., et al. J. Invest. Dermatol. 119(4):913-919(2002)Min, J.H., et al. Biochemistry 40(15):4539-4549(2001)
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