PAFAH2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q99487 |
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Clone Names | 110617190 |
Gene ID | 5051 |
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Other Names | Platelet-activating factor acetylhydrolase 2, cytoplasmic, Serine-dependent phospholipase A2, SD-PLA2, hSD-PLA2, PAFAH2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PAFAH2 (HGNC:8579) |
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Function | Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation (PubMed:9494101). Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (By similarity). Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2- ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (By similarity). |
Cellular Location | Cytoplasm. Membrane {ECO:0000250|UniProtKB:P79106}; Lipid-anchor {ECO:0000250|UniProtKB:P79106}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P79106}; Lipid-anchor {ECO:0000250|UniProtKB:P79106}. Note=In resting cells, localizes to intracellular membranes and cytoplasm. Translocates from the cytoplasm to intracellular membranes upon oxidative stress {ECO:0000250|UniProtKB:P79106} |
Tissue Location | Broadly expressed in different tissues, but high in B- and T-lymphocytes. In brain, expression is restricted to amygdala and frontal cortex. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes platelet-activating factoracetylhydrolase isoform 2, a single-subunit intracellular enzymethat catalyzes the removal of the acetyl group at the SN-2 positionof platelet-activating factor (identified as1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, thislipase exhibits a broader substrate specificity than simplyplatelet activating factor. Two other isoforms of intracellularplatelet-activating factor acetylhydrolase exist, and both aremulti-subunit enzymes. Additionally, there is a single-subunitserum isoform of this enzyme.
References
Schmidt, E.B., et al. Atherosclerosis 196(1):420-424(2008)Umemura, K., et al. Stroke 38(3):1063-1068(2007)Unno, N., et al. J. Surg. Res. 134(1):36-43(2006)Marques, M., et al. J. Invest. Dermatol. 119(4):913-919(2002)Min, J.H., et al. Biochemistry 40(15):4539-4549(2001)
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