|Other Names||Steroid receptor RNA activator 1, Steroid receptor RNA activator protein, SRAP, SRA1 (HGNC:11281)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up- regulated in human tumors of the breast, ovary, and uterus|
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This gene is involved in transcriptional coactivation bysteroid receptors. There is currently data suggesting this geneencodes both a non-coding RNA that functions as part of aribonucleoprotein complex and a protein coding mRNA. Increasedexpression of both the transcript and the protein is associatedwith cancer.
Yao, H., et al. Genes Dev. 24(22):2543-2555(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Beauvillain, C., et al. J. Hepatol. 52(5):644-651(2010)Foulds, C.E., et al. Mol. Endocrinol. 24(5):1090-1105(2010)Chooniedass-Kothari, S., et al. FEBS Lett. 584(6):1174-1180(2010)
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