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SNF8 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96H20
Clone Names 100517182
Peptide ID 100517182
Additional Information
Gene ID 11267
Other Names Vacuolar-sorting protein SNF8, ELL-associated protein of 30 kDa, ESCRT-II complex subunit VPS22, hVps22, SNF8, EAP30
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNF8
Synonyms EAP30
Function Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.
Cellular Location Cytoplasm. Endosome membrane. Nucleus. Late endosome membrane. Note=Recruited to the endosome membrane to participate in vesicle formation
Research Areas
Citations (0)

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SNF8, VPS25 (MIM 610907), and VPS36 (MIM 610903) formESCRT-II (endosomal sorting complex required for transport II), acomplex involved in endocytosis of ubiquitinated membrane proteins.SNF8, VPS25, and VPS36 are also associated in a multiproteincomplex with RNA polymerase II elongation factor (ELL; MIM 600284)(Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001[PubMed 11278625]).


Malerod, L., et al. Traffic 8(11):1617-1629(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Langelier, C., et al. J. Virol. 80(19):9465-9480(2006)Bowers, K., et al. J. Biol. Chem. 281(8):5094-5105(2006)Slagsvold, T., et al. J. Biol. Chem. 280(20):19600-19606(2005)

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$ 80.00
Cat# BP17410a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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