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BBS7 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8IWZ6
Clone Names 110617137
Peptide ID 110617137
Additional Information
Gene ID 55212
Other Names Bardet-Biedl syndrome 7 protein, BBS2-like protein 1, BBS7, BBS2L1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BBS7
Synonyms BBS2L1
Function The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.
Cellular Location Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
Tissue Location Isoform 2 is ubiquitously expressed. Isoform 1 is expressed in retina, lung, liver, testis, ovary, prostate, small intestine, liver, brain, heart and pancreas
Research Areas
Citations (0)

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Mutations in this gene have been observed in patients withBardet-Biedl syndrome type 7. The encoded protein may play a rolein eye, limb, cardiac and reproductive system development. Twotranscript variants encoding distinct isoforms have been identifiedfor this gene.


Bin, J., et al. Hum. Mutat. 30 (7), E737-E746 (2009) :Chung, W.K., et al. Hum. Hered. 67(3):193-205(2009)Oeffner, F., et al. Cell Motil. Cytoskeleton 65(2):143-155(2008)Yang, Z., et al. Mol. Vis. 14, 2304-2308 (2008) :Nachury, M.V., et al. Cell 129(6):1201-1213(2007)

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$ 80.00
Cat# BP17417a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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