PTPN23 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H3S7 |
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Clone Names | 110617227 |
Gene ID | 25930 |
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Other Names | Tyrosine-protein phosphatase non-receptor type 23, His domain-containing protein tyrosine phosphatase, HD-PTP, Protein tyrosine phosphatase TD14, PTP-TD14, PTPN23, KIAA1471 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PTPN23 |
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Synonyms | KIAA1471 |
Function | Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563). |
Cellular Location | Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body. Early endosome |
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Provided below are standard protocols that you may find useful for product applications.
Background
PTPN23 may act as a negative regulator of Ras-mediated mitogenic activity.
References
Mariotti, M., et al. Int. J. Biochem. Cell Biol. 41(3):687-693(2009)Mariotti, M., et al. Cancer Lett. 273(1):155-163(2009)Gingras, M.C., et al. PLoS ONE 4 (4), E5105 (2009) :Castiglioni, S., et al. Biochem. Biophys. Res. Commun. 364(3):534-539(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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