|Other Names||Tyrosine-protein phosphatase non-receptor type 23, His domain-containing protein tyrosine phosphatase, HD-PTP, Protein tyrosine phosphatase TD14, PTP-TD14, PTPN23, KIAA1471|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body. Early endosome|
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Provided below are standard protocols that you may find useful for product applications.
PTPN23 may act as a negative regulator of Ras-mediated mitogenic activity.
Mariotti, M., et al. Int. J. Biochem. Cell Biol. 41(3):687-693(2009)Mariotti, M., et al. Cancer Lett. 273(1):155-163(2009)Gingras, M.C., et al. PLoS ONE 4 (4), E5105 (2009) :Castiglioni, S., et al. Biochem. Biophys. Res. Commun. 364(3):534-539(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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