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TACC1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O75410 |
|---|---|
| Clone Names | 100623263 |
| Gene ID | 6867 |
|---|---|
| Other Names | Transforming acidic coiled-coil-containing protein 1, Gastric cancer antigen Ga55, Taxin-1, TACC1, KIAA1103 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TACC1 |
|---|---|
| Synonyms | KIAA1103 |
| Function | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. |
| Cellular Location | Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. [Isoform 10]: Cytoplasm |
| Tissue Location | Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer |
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Provided below are standard protocols that you may find useful for product applications.
Background
This locus may represent a breast cancer candidate gene.It is located close to FGFR1 on a region of chromosome 8 that isamplified in some breast cancers. Three transcript variantsencoding different isoforms have been found for this gene.
References
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Guyot, R., et al. BMC Mol. Biol. 11, 3 (2010) :Ghayad, S.E., et al. J. Mol. Endocrinol. 42(2):87-103(2009)Olsen, J.V., et al. Cell 127(3):635-648(2006)Lauffart, B., et al. Dev. Dyn. 235(6):1638-1647(2006)
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