|Other Names||Serine/arginine-rich splicing factor 10, 40 kDa SR-repressor protein, SRrp40, FUS-interacting serine-arginine-rich protein 1, Splicing factor SRp38, Splicing factor, arginine/serine-rich 13A, TLS-associated protein with Ser-Arg repeats, TASR, TLS-associated protein with SR repeats, TLS-associated serine-arginine protein, TLS-associated SR protein, SRSF10, FUSIP1, FUSIP2, SFRS13A, TASR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||FUSIP1, FUSIP2, SFRS13A, TASR|
|Function||Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250).|
|Cellular Location||Nucleus speckle Cytoplasm|
|Tissue Location||Widely expressed.|
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This gene product is a member of the serine-arginine (SR)family of proteins, which is involved in constitutive and regulatedRNA splicing. Members of this family are characterized byN-terminal RNP1 and RNP2 motifs, which are required for binding toRNA, and multiple C-terminal SR/RS repeats, which are important inmediating association with other cellular proteins. This proteincan influence splice site selection of adenovirus E1A pre-mRNA. Itinteracts with the oncoprotein TLS, and abrogates the influence ofTLS on E1A pre-mRNA splicing. This gene has multiple pseudogenes.Alternative splicing of this gene results in multiple transcriptvariants encoding different isoforms. In addition, transcriptvariants utilizing alternative polyA sites exist.
Manley, J.L., et al. Genes Dev. 24(11):1073-1074(2010)Ling, I.F., et al. Hum. Mutat. 31(6):702-709(2010)Shi, Y., et al. Mol. Cell 28(1):79-90(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Lareau, L.F., et al. Nature 446(7138):926-929(2007)
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