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SMUG1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q53HV7
Clone Names 100623283
Peptide ID 100623283
Additional Information
Gene ID 23583
Other Names Single-strand selective monofunctional uracil DNA glycosylase, 322-, SMUG1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMUG1
Function Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5- formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5- hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration.
Cellular Location Nucleus
Research Areas
Citations (0)

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SMUG1 is a glycosylase that removes uracil from single-and double-stranded DNA in nuclear chromatin, thus contributing tobase excision repair.


Arora, M., et al. Leukemia 24(8):1470-1475(2010)Thyagarajan, B., et al. Biol. Blood Marrow Transplant. 16(8):1084-1089(2010)Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)Chanson, A., et al. Am. J. Clin. Nutr. 89(6):1927-1936(2009)Knaevelsrud, I., et al. Int. J. Radiat. Biol. 85(5):413-420(2009)

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$ 80.00
Cat# BP17422a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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