|Other Names||Src kinase-associated phosphoprotein 2, Pyk2/RAFTK-associated protein, Retinoic acid-induced protein 70, SKAP55 homolog, SKAP-55HOM, SKAP-HOM, Src family-associated phosphoprotein 2, Src kinase-associated phosphoprotein 55-related protein, Src-associated adapter protein with PH and SH3 domains, SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP55R|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||PRAP, RA70, SAPS, SCAP2, SKAP55R|
|Function||May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.|
|Tissue Location||Ubiquitously expressed. Present in platelets (at protein level).|
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The protein encoded by this gene belongs to the src familykinases. This protein is similar to the src kinase associatedphosphoprotein 1. It is an adaptor protein that is thought to playan essential role in the src signaling pathway in various cells. Itinhibits PTK2B/RAFTK activity and regulates alpha-synucleinphosphorylation.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Qu, H.Q., et al. Hum. Mol. Genet. 19(12):2534-2538(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Barrett, J.C., et al. Nat. Genet. 41(6):703-707(2009)Voss, M., et al. BMC Immunol. 10, 53 (2009) :
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