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AP2S1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P53680
Clone Names 100712188
Peptide ID 100712188
Additional Information
Gene ID 1175
Other Names AP-2 complex subunit sigma, Adaptor protein complex AP-2 subunit sigma, Adaptor-related protein complex 2 subunit sigma, Clathrin assembly protein 2 sigma small chain, Clathrin coat assembly protein AP17, Clathrin coat-associated protein AP17, HA2 17 kDa subunit, Plasma membrane adaptor AP-2 17 kDa protein, Sigma2-adaptin, AP2S1, AP17, CLAPS2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AP2S1
Synonyms AP17, CLAPS2
Function Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). May also play a role in extracellular calcium homeostasis.
Cellular Location Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV
Research Areas
Citations (0)

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One of two major clathrin-associated adaptor complexes,AP-2, is a heterotetramer which is associated with the plasmamembrane. This complex is composed of two large chains, a mediumchain, and a small chain. This gene encodes the small chain of thiscomplex. Alternative splicing has been observed in this gene andresults in two known transcripts.


Stove, V., et al. J. Virol. 79(17):11422-11433(2005)Lu, W., et al. Neuron 47(3):407-421(2005)Collins, B.M., et al. Cell 109(4):523-535(2002)Yano, H., et al. J. Neurosci. 21 (3), RC125 (2001) :Pearse, B.M., et al. Curr. Opin. Struct. Biol. 10(2):220-228(2000)

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$ 80.00
Cat# BP17428c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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