|Other Names||Myozenin-2, Calsarcin-1, FATZ-related protein 2, MYOZ2 (HGNC:1330)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.|
|Cellular Location||Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with ACTN1 and PPP3CA at the Z- line of heart and skeletal muscle.|
|Tissue Location||Expressed specifically in heart and skeletal muscle.|
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MYOZ2 myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)Xin, X., et al. Genome Res. 19(7):1262-1269(2009)Aurino, S., et al. Acta Myol 27, 90-97 (2008) :Posch, M.G., et al. Med. Sci. Monit. 14 (7), CR372-CR374 (2008) :Posch, M.G., et al. Mol. Genet. Metab. 91(2):207-208(2007)
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