|Other Names||DNA primase large subunit, 277-, DNA primase 58 kDa subunit, p58, PRIM2, PRIM2A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.|
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Provided below are standard protocols that you may find useful for product applications.
The replication of DNA in eukaryotic cells is carried outby a complex chromosomal replication apparatus, in which DNApolymerase alpha and primase are two key enzymatic components.Primase, which is a heterodimer of a small subunit and a largesubunit, synthesizes small RNA primers for the Okazaki fragmentsmade during discontinuous DNA replication. The protein encoded bythis gene is the large, 58 kDa primase subunit. [provided byRefSeq].
Vaithiyalingam, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(31):13684-13689(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Weiner, B.E., et al. J. Biol. Chem. 282(46):33444-33451(2007)Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)Mungall, A.J., et al. Nature 425(6960):805-811(2003)
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