QPCT Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q16769 |
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Clone Names | 100712281 |
Gene ID | 25797 |
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Other Names | Glutaminyl-peptide cyclotransferase, Glutaminyl cyclase, QC, sQC, Glutaminyl-tRNA cyclotransferase, Glutamyl cyclase, EC, QPCT |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | QPCT |
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Function | Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N- terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides. |
Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes human pituitary glutaminyl cyclase,which is responsible for the presence of pyroglutamyl residues inmany neuroendocrine peptides. The amino acid sequence of thisenzyme is 86% identical to that of bovine glutaminyl cyclase.
References
Morawski, M., et al. Acta Neuropathol. 120(2):195-207(2010)Stephan, A., et al. FEBS J. 276(22):6522-6536(2009)Marroni, F., et al. Circ Cardiovasc Genet 2(4):322-328(2009)Calvaresi, M., et al. Proteins 73(3):527-538(2008)Cynis, H., et al. J. Mol. Biol. 379(5):966-980(2008)
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