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Mouse Sik2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8CFH6 |
|---|---|
| Clone Names | 110328084 |
| Gene ID | 235344 |
|---|---|
| Other Names | Serine/threonine-protein kinase SIK2, Salt-inducible kinase 2, SIK-2, Serine/threonine-protein kinase SNF1-like kinase 2, Sik2, Snf1lk2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Sik2 |
|---|---|
| Synonyms | Snf1lk2 |
| Function | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:12624099, PubMed:16817901, PubMed:29211348). Phosphorylates 'Ser-794' of IRS1 in insulin- stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction (PubMed:12624099). Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:16817901). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity. In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (By similarity). Also plays a role in thymic T-cell development (PubMed:34732767). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Present in both white and brown adipose tissues with levels increasing during adipocyte differentiation. Lower levels observed in the testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
References
Trivedi, C.M., et al. Dev. Cell 19(3):450-459(2010)Muraoka, M., et al. Am. J. Physiol. Endocrinol. Metab. 296 (6), E1430-E1439 (2009) :Du, J., et al. Obesity (Silver Spring) 16(3):531-538(2008)Katoh, Y., et al. FEBS J. 273(12):2730-2748(2006)Horike, N., et al. J. Biol. Chem. 278(20):18440-18447(2003)
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