|Other Names||Serine/threonine-protein kinase VRK2, Vaccinia-related kinase 2, Vrk2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates histone H3. Phosphorylates 'Thr-18' of p53/TP53, and thereby increases its stability and activity. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. May also phosphorylate MAPK8IP1. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant (By similarity).|
|Cellular Location||Cytoplasm. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Mitochondrion membrane; Single-pass type IV membrane protein|
|Tissue Location||Expressed in liver, kidney and muscle. Weakly expressed in thymus, bone marrow and spleen|
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Provided below are standard protocols that you may find useful for product applications.
Probable serine/threonine kinase (By similarity).
Bailey, P.J., et al. Exp. Cell Res. 312(16):3108-3119(2006)Wang, S., et al. PLoS Genet. 2 (2), E15 (2006) :Nichols, R.J., et al. J. Biol. Chem. 279(9):7934-7946(2004)Vega, F.M., et al. FEBS Lett. 544 (1-3), 176-180 (2003) :Agoulnik, A.I., et al. Hum. Mol. Genet. 11(24):3047-3053(2002)
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