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Mouse Vrk2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8BN21
Clone Names 110328153
Peptide ID 110328153
Additional Information
Gene ID 69922
Other Names Serine/threonine-protein kinase VRK2, Vaccinia-related kinase 2, Vrk2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Vrk2
Function Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates histone H3. Phosphorylates 'Thr-18' of p53/TP53, and thereby increases its stability and activity. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. May also phosphorylate MAPK8IP1. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant (By similarity).
Cellular Location Cytoplasm. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Mitochondrion membrane; Single-pass type IV membrane protein
Tissue Location Expressed in liver, kidney and muscle. Weakly expressed in thymus, bone marrow and spleen
Research Areas
Citations (0)

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Probable serine/threonine kinase (By similarity).


Bailey, P.J., et al. Exp. Cell Res. 312(16):3108-3119(2006)Wang, S., et al. PLoS Genet. 2 (2), E15 (2006) :Nichols, R.J., et al. J. Biol. Chem. 279(9):7934-7946(2004)Vega, F.M., et al. FEBS Lett. 544 (1-3), 176-180 (2003) :Agoulnik, A.I., et al. Hum. Mol. Genet. 11(24):3047-3053(2002)

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$ 80.00
Cat# BP17443b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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