|Other Names||Histone H2A type 1-B/E, Histone H2A2, Histone H2A/a, Histone H2A/m, HIST1H2AB, H2AFM|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|
|Cellular Location||Nucleus. Chromosome.|
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Provided below are standard protocols that you may find useful for product applications.
Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. This structure consists of approximately 146 bp of DNAwrapped around a nucleosome, an octamer composed of pairs of eachof the four core histones (H2A, H2B, H3, and H4). The chromatinfiber is further compacted through the interaction of a linkerhistone, H1, with the DNA between the nucleosomes to form higherorder chromatin structures. This gene is intronless and encodes amember of the histone H2A family. Transcripts from this gene lackpolyA tails; instead, they contain a palindromic terminationelement. This gene is found in the large histone gene cluster onchromosome 6p22-p21.3.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Bergink, S., et al. Genes Dev. 20(10):1343-1352(2006)Cao, R., et al. Mol. Cell 20(6):845-854(2005)Hagiwara, T., et al. Biochemistry 44(15):5827-5834(2005)Andersen, J.S., et al. Nature 433(7021):77-83(2005)
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