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ARID5B Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q14865
Clone Names 110617086
Peptide ID 110617086
Additional Information
Gene ID 84159
Other Names AT-rich interactive domain-containing protein 5B, ARID domain-containing protein 5B, MRF1-like protein, Modulator recognition factor 2, MRF-2, ARID5B, DESRT, MRF2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms DESRT, MRF2
Function Transcription coactivator that binds to the 5'-AATA[CT]- 3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2- ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00355}
Tissue Location Widely expressed, including in liver (at protein level).
Research Areas
Citations (0)

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DNA-binding protein that binds to the 5'-AATA[CT]-3' core sequence. Probably acts as a transcription regulator. Represses the cytomegalovirus enhancer. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may act as a regulator of smooth muscle cell differentiation and proliferation. May be involved in lipid stores.


Healy, J., et al. Haematologica 95(9):1608-1611(2010)Yang, W., et al. Leukemia 24(4):894-896(2010)Prasad, R.B., et al. Blood 115(9):1765-1767(2010)Papaemmanuil, E., et al. Nat. Genet. 41(9):1006-1010(2009)Trevino, L.R., et al. Nat. Genet. 41(9):1001-1005(2009)

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$ 80.00
Cat# BP17449c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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