ARID5B Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q14865 |
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Clone Names | 110617086 |
Gene ID | 84159 |
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Other Names | AT-rich interactive domain-containing protein 5B, ARID domain-containing protein 5B, MRF1-like protein, Modulator recognition factor 2, MRF-2, ARID5B, DESRT, MRF2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ARID5B |
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Synonyms | DESRT, MRF2 |
Function | Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355}. |
Tissue Location | Widely expressed, including in liver (at protein level). |
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Background
DNA-binding protein that binds to the 5'-AATA[CT]-3' core sequence. Probably acts as a transcription regulator. Represses the cytomegalovirus enhancer. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may act as a regulator of smooth muscle cell differentiation and proliferation. May be involved in lipid stores.
References
Healy, J., et al. Haematologica 95(9):1608-1611(2010)Yang, W., et al. Leukemia 24(4):894-896(2010)Prasad, R.B., et al. Blood 115(9):1765-1767(2010)Papaemmanuil, E., et al. Nat. Genet. 41(9):1006-1010(2009)Trevino, L.R., et al. Nat. Genet. 41(9):1001-1005(2009)
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