METTL13 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8N6R0 |
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Clone Names | 110617145 |
Gene ID | 51603 |
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Other Names | Methyltransferase-like protein 13, 211-, METTL13, KIAA0859 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | METTL13 (HGNC:24248) |
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Function | Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation (PubMed:30612740, PubMed:30143613). Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2' (PubMed:30143613). Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55' (PubMed:30612740, PubMed:30143613). Has no activity towards core histones H2A, H2B, H3 and H4 (PubMed:30612740). Negatively regulates cell proliferation at G1/S transition via transcriptional suppression of cell cycle regulatory genes such as CDK4 and CDK6 (PubMed:26763933). |
Cellular Location | Cytoplasm. Nucleus. Mitochondrion |
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Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein remains unknown.
References
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
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