|Other Names||Vam6/Vps39-like protein, TRAP1-like protein, hVam6p, VPS39, KIAA0770, TLP, VAM6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0770, TLP, VAM6|
|Function||May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation.|
|Cellular Location||Cytoplasm. Lysosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles|
|Tissue Location||Widely expressed, with highest levels in heart, skeletal muscle, kidney, pancreas, brain, placenta and spleen.|
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This gene encodes a protein that may promote clusteringand fusion of late endosomes and lysosomes. The protein may alsoact as an adaptor protein that modulates the transforming growthfactor-beta response by coupling the transforming growthfactor-beta receptor complex to the Smad pathway. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Peralta, E.R., et al. J. Biol. Chem. 285(22):16814-16821(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Zhu, G.D., et al. Mol. Biol. Cell 20(4):1223-1240(2009)Felici, A., et al. EMBO J. 22(17):4465-4477(2003)
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