|Other Names||SPARC-related modular calcium-binding protein 2, Secreted modular calcium-binding protein 2, SMOC-2, Smooth muscle-associated protein 2, SMAP-2, SMOC2, SMAP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation, migration, as well as angiogenesis.|
|Cellular Location||Secreted, extracellular space, extracellular matrix, basement membrane|
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This gene encodes a member of the SPARC family (secretedprotein acidic and rich in cysteine/osteonectin/BM-40), which arehighly expressed during embryogenesis and wound healing. The geneproduct is a matricellular protein which promotes matrix assemblyand can stimulate endothelial cell proliferation and migration, aswell as angiogenic activity. Associated with pulmonary function,this secretory gene product contains a Kazal domain, twothymoglobulin type-1 domains, and two EF-hand calcium-bindingdomains. The encoded protein may serve as a target for controllingangiogenesis in tumor growth and myocardial ischemia. Alternativesplicing results in multiple transcript variants. [provided byRefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Birlea, S.A., et al. J. Invest. Dermatol. 130(3):798-803(2010)Wilk, J.B., et al. Am. J. Respir. Crit. Care Med. 175(6):554-560(2007)Rocnik, E.F., et al. J. Biol. Chem. 281(32):22855-22864(2006)Vannahme, C., et al. Biochem. J. 373 (PT 3), 805-814 (2003) :
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