ZNF346 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UL40 |
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Clone Names | 110717235 |
Gene ID | 23567 |
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Other Names | Zinc finger protein 346, Just another zinc finger protein, ZNF346, JAZ |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ZNF346 |
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Synonyms | JAZ |
Function | Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed:24521053). May bind to specific miRNA hairpins (PubMed:28431233). |
Cellular Location | Nucleus, nucleolus. Cytoplasm. Note=Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5 |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a nucleolar, zincfinger protein that preferentially binds to double-stranded (ds)RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studiesindicate that the zinc finger domains are not only essential fordsRNA binding, but are also required for its nucleolarlocalization. The encoded protein may be involved in cell growthand survival.
References
Chen, T., et al. Mol. Cell. Biol. 24(15):6608-6619(2004)Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)Yang, M., et al. J. Biol. Chem. 274(39):27399-27406(1999)
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