|Other Names||Zinc finger protein 346, Just another zinc finger protein, ZNF346, JAZ|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity.|
|Cellular Location||Nucleus, nucleolus. Cytoplasm. Note=Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a nucleolar, zincfinger protein that preferentially binds to double-stranded (ds)RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studiesindicate that the zinc finger domains are not only essential fordsRNA binding, but are also required for its nucleolarlocalization. The encoded protein may be involved in cell growthand survival.
Chen, T., et al. Mol. Cell. Biol. 24(15):6608-6619(2004)Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)Yang, M., et al. J. Biol. Chem. 274(39):27399-27406(1999)
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