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OSBPL6 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BZF3 |
|---|---|
| Clone Names | 110726149 |
| Gene ID | 114880 |
|---|---|
| Other Names | Oxysterol-binding protein-related protein 6, ORP-6, OSBP-related protein 6, OSBPL6, ORP6 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | OSBPL6 |
|---|---|
| Synonyms | ORP6 |
| Function | Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). |
| Cellular Location | Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus envelope. Cell membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Co-localizes with OSBPL3 at contact sites between the plasma membrane and the endoplasmic reticulum {ECO:0000250|UniProtKB:Q8BXR9} |
| Tissue Location | Expressed in brain and striated muscle (at protein level) (PubMed:14593528). Widely expressed (PubMed:11735225). Expressed in skeletal muscle (PubMed:14593528) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the oxysterol-bindingprotein (OSBP) family, a group of intracellular lipid receptors.Most members contain an N-terminal pleckstrin homology domain and ahighly conserved C-terminal OSBP-like sterol-binding domain.Transcript variants encoding different isoforms have beenidentified.
References
Maestrini, E., et al. Mol. Psychiatry 15(9):954-968(2010)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Lehto, M., et al. Cell Tissue Res. 315(1):39-57(2004)Jaworski, C.J., et al. Genomics 78(3):185-196(2001)Lehto, M., et al. J. Lipid Res. 42(8):1203-1213(2001)
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