|Other Names||Ras-related protein Rab-32, RAB32|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.|
|Cellular Location||Mitochondrion. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side Note=Recruited to phagosomes containing S.aureus or M.tuberculosis|
|Tissue Location||Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung|
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Provided below are standard protocols that you may find useful for product applications.
Small GTP-binding proteins of the RAB family, such asRAB32, play essential roles in vesicle and granule targeting (Baoet al., 2002 [PubMed 11784320]).
Hirota, Y., et al. Cell. Mol. Life Sci. 66(17):2913-2932(2009)Shibata, D., et al. Int. J. Cancer 119(4):801-806(2006)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Alto, N.M., et al. J. Cell Biol. 158(4):659-668(2002)Bao, X., et al. Eur. J. Biochem. 269(1):259-271(2002)
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