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RAB32 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13637 |
|---|---|
| Clone Names | 110726180 |
| Gene ID | 10981 |
|---|---|
| Other Names | Ras-related protein Rab-32, RAB32 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RAB32 |
|---|---|
| Function | Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). |
| Cellular Location | Mitochondrion. Mitochondrion outer membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Melanosome {ECO:0000250|UniProtKB:Q9CZE3}. Melanosome membrane. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991). |
| Tissue Location | Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Small GTP-binding proteins of the RAB family, such asRAB32, play essential roles in vesicle and granule targeting (Baoet al., 2002 [PubMed 11784320]).
References
Hirota, Y., et al. Cell. Mol. Life Sci. 66(17):2913-2932(2009)Shibata, D., et al. Int. J. Cancer 119(4):801-806(2006)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Alto, N.M., et al. J. Cell Biol. 158(4):659-668(2002)Bao, X., et al. Eur. J. Biochem. 269(1):259-271(2002)
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