|Other Names||Ubiquitin-like domain-containing CTD phosphatase 1, Nuclear proteasome inhibitor UBLCP1, UBLCP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.|
|Cellular Location||Nucleus. Note=Colocalizes with nuclear proteasomes|
|Tissue Location||Broadly expressed, with highest levels in placenta, lung, testis and ovary. Up-regulated in tumor tissues|
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Provided below are standard protocols that you may find useful for product applications.
UBLCP1 may specifically dephosphorylate 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit.
Nair, R.P., et al. Nat. Genet. 41(2):199-204(2009)Zheng, H., et al. Biochem. Biophys. Res. Commun. 331(4):1401-1407(2005)
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