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RGMB Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6NW40 |
|---|---|
| Clone Names | 100617151 |
| Gene ID | 285704 |
|---|---|
| Other Names | RGM domain family member B, DRG11-responsive axonal guidance and outgrowth of neurite, DRAGON, RGMB |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RGMB {ECO:0000303|PubMed:19324014, ECO:0000312|HGNC:HGNC:26896} |
|---|---|
| Function | Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q7TQ33}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q7TQ33}. Membrane raft {ECO:0000250|UniProtKB:Q7TQ33} |
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Provided below are standard protocols that you may find useful for product applications.
Background
RGMB is a glycosylphosphatidylinositol (GPI)-anchoredmember of the repulsive guidance molecule family (see RGMA, MIM607362) and contributes to the patterning of the developing nervoussystem (Samad et al., 2005 [PubMed 15671031]).
References
Samad, T.A., et al. J. Biol. Chem. 280(14):14122-14129(2005)Samad, T.A., et al. J. Neurosci. 24(8):2027-2036(2004)
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