|Other Names||RGM domain family member B, DRG11-responsive axonal guidance and outgrowth of neurite, DRAGON, RGMB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft|
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Provided below are standard protocols that you may find useful for product applications.
RGMB is a glycosylphosphatidylinositol (GPI)-anchoredmember of the repulsive guidance molecule family (see RGMA, MIM607362) and contributes to the patterning of the developing nervoussystem (Samad et al., 2005 [PubMed 15671031]).
Samad, T.A., et al. J. Biol. Chem. 280(14):14122-14129(2005)Samad, T.A., et al. J. Neurosci. 24(8):2027-2036(2004)
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