|Other Names||Transcription elongation factor A protein-like 1, TCEA-like protein 1, Nuclear phosphoprotein p21/SIIR, Transcription elongation factor S-II protein-like 1, TCEAL1, SIIR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context- dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly.|
|Tissue Location||Expressed in all tissues examined. Highly expressed in heart, ovary, prostate and skeletal muscle Moderately expressed in brain, placenta, testis and small intestine. Weakly expressed in lung, liver and spleen. Expressed in several cancer cell lines.|
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This gene encodes a member of the transcription elongationfactor A (SII)-like (TCEAL) gene family. Members of this family mayfunction as nuclear phosphoproteins that modulate transcription ina promoter context-dependent manner. The encoded protein is similarto transcription elongation factor A/transcription factor SII andcontains a zinc finger-like motif as well as a sequence related tothe transcription factor SII Pol II-binding region. It may exertits effects via protein-protein interactions with othertranscriptional regulators rather than via direct binding of DNA.Multiple family members are located on the X chromosome.Alternative splicing results in multiple transcript variantsencoding a single isoform.
Chung, C.J., et al. Toxicol. Appl. Pharmacol. 232(2):203-209(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)Lee, Y.L., et al. J. Lab. Clin. Med. 147(5):228-233(2006)Santos, A.M., et al. Eur. J. Cancer 42(7):958-963(2006)Santos, A.M., et al. Biochem. Biophys. Res. Commun. 340(1):256-262(2006)
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