Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
NOXO1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8NFA2 |
|---|---|
| Clone Names | 100712320 |
| Gene ID | 124056 |
|---|---|
| Other Names | NADPH oxidase organizer 1, NADPH oxidase regulatory protein, Nox organizer 1, Nox-organizing protein 1, SH3 and PX domain-containing protein 5, NOXO1, P41NOX, SH3PXD5 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NOXO1 |
|---|---|
| Synonyms | P41NOX, SH3PXD5 |
| Function | Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. |
| Cellular Location | [Isoform 3]: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner (PubMed:12716910) |
| Tissue Location | Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon Isoform 1 is preferentially expressed in testis |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
NADPH oxidases (NOXs) catalyze the transfer of electronsfrom NADPH to molecular oxygen to generate reactive oxygen species(ROS). NOX organizers, such as NOXO1, target NOX activators (seeNOXA1; MIM 611255) to NOX and also target NOX to differentsubcellular compartments (Opitz et al., 2007 [PubMed17189823]).
References
Dutta, S., et al. PLoS ONE 5 (5), E10478 (2010) :Opitz, N., et al. Free Radic. Biol. Med. 42(2):175-179(2007)Yamamoto, A., et al. Biochem. Biophys. Res. Commun. 352(2):560-565(2007)Takeya, R., et al. FEBS J. 273(16):3663-3677(2006)Cheng, G., et al. J. Biol. Chem. 281(26):17718-17726(2006)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
