|Other Names||Carbohydrate sulfotransferase 10, 282-, HNK-1 sulfotransferase, HNK-1ST, HNK1ST, HuHNK-1ST, CHST10|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||In fetal tissues, it is predominantly expressed in brain, and weakly expressed in lung, kidney and liver. In adult, it is highly expressed in brain, testis, ovary, expressed at intermediate level in heart, pancreas, skeletal muscle, spleen and thymus, and weakly expressed in other tissues In brain, it is expressed at higher level in the frontal lobe|
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Provided below are standard protocols that you may find useful for product applications.
Cell surface carbohydrates modulate a variety of cellularfunctions and are typically synthesized in a stepwise manner.HNK1ST plays a role in the biosynthesis of HNK1 (see MIM 151290), aneuronally expressed carbohydrate that contains a sulfoglucuronylresidue.
Zhao, X., et al. Cancer Res. 69(12):5218-5225(2009)Kang, H.G., et al. J. Biol. Chem. 277(38):34766-34772(2002)Ong, E., et al. J. Biol. Chem. 274(36):25608-25612(1999)Ong, E., et al. J. Biol. Chem. 273(9):5190-5195(1998)
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