|Other Names||Aminopeptidase O, AP-O, 3411-, AOPEP, C9orf3, ONPEP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart.|
|Tissue Location||Predominantly expressed in pancreas, placenta, liver, testis and heart. Expressed at lower level in brain, lung and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the M1 zinc aminopeptidasefamily. The encoded protein is a zinc-dependent metallopeptidasethat catalyzes the removal of an amino acid from the amino terminusof a protein or peptide. This protein may play a role in thegeneration of angiotensin IV. Alternate splicing results inmultiple transcript variants.
Diaz-Perales, A., et al. J. Biol. Chem. 280(14):14310-14317(2005)Humphray, S.J., et al. Nature 429(6990):369-374(2004)
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