|Other Names||C-type lectin domain family 4 member D, C-type lectin superfamily member 8, C-type lectin-like receptor 6, CLEC-6, CLEC4D, CLECSF8, MCL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the C-type lectin/C-typelectin-like domain (CTL/CTLD) superfamily. Members of this familyshare a common protein fold and have diverse functions, such ascell adhesion, cell-cell signalling, glycoprotein turnover, androles in inflammation and immune response. This gene is closelylinked to other CTL/CTLD superfamily members on chromosome 12p13 inthe natural killer gene complex region.
Flornes, L.M., et al. Immunogenetics 56(7):506-517(2004)Arce, I., et al. Eur. J. Immunol. 34(1):210-220(2004)Ebner, S., et al. Proteins 53(1):44-55(2003)Drickamer, K. Curr. Opin. Struct. Biol. 9(5):585-590(1999)
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