|Other Names||Cytochrome P450 4V2, 11413-, Docosahexaenoic acid omega-hydroxylase CYP4V2, CYP4V2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye (PubMed:19661213, PubMed:22772592). Catalyzes the omega- hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (PubMed:19661213). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:22772592). Also produces some 21-hydroxydocosahexaenoate. Also converts eicosapentaenoate (EPA) to 20- hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:22772592).|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass membrane protein|
|Tissue Location||Broadly expressed. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium (RPE) and lymphocytes|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the cytochrome P450hemethiolate protein superfamily which are involved in oxidizingvarious substrates in the metabolic pathway. It is implicated inthe metabolism of fatty acid precursors into n-3 polyunsaturatedfatty acids.
Yokoi, Y., et al. Acta Ophthalmol 88(5):607-609(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Pelak, K., et al. J. Infect. Dis. 201(8):1141-1149(2010)Nakano, M., et al. Drug Metab. Dispos. 37(11):2119-2122(2009)Li, Y., et al. J. Thromb. Haemost. 7(11):1802-1808(2009)
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