|Other Names||Protein-glutamine gamma-glutamyltransferase E, Transglutaminase E, TG(E), TGE, TGase E, Transglutaminase-3, TGase-3, Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain, Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain, TGM3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross- linking structural proteins to hardening the inner root sheath.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Transglutaminases are enzymes that catalyze thecrosslinking of proteins by epsilon-gamma glutamyl lysineisopeptide bonds. While the primary structure of transglutaminasesis not conserved, they all have the same amino acid sequence attheir active sites and their activity is calcium-dependent. Theprotein encoded by this gene consists of two polypeptide chainsactivated from a single precursor protein by proteolysis. Theencoded protein is involved the later stages of cell envelopeformation in the epidermis and hair follicle.
Yamane, A., et al. FEBS J. 277(17):3564-3574(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Negishi, A., et al. Cancer Sci. 100(9):1605-1611(2009)Fujimoto, A., et al. J. Hum. Genet. 54(8):461-465(2009)Uemura, N., et al. Int. J. Cancer 124(9):2106-2115(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.