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WIPI1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q5MNZ9
Clone Names 80410102
Peptide ID 80410102
Additional Information
Gene ID 55062
Other Names WD repeat domain phosphoinositide-interacting protein 1, WIPI-1, Atg18 protein homolog, WD40 repeat protein interacting with phosphoinositides of 49 kDa, WIPI 49 kDa, WIPI1, WIPI49
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name WIPI1
Synonyms WIPI49
Function Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation- induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.
Cellular Location Golgi apparatus, trans-Golgi network. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle Preautophagosomal structure membrane; Peripheral membrane protein Cytoplasm, cytoskeleton. Note=Trans elements of the Golgi and peripheral endosomes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriched in clathrin-coated vesicles. Upon starvation-induced autophagy, accumulates at subcellular structures in the cytoplasm: enlarged vesicular and lasso-like structures, and large cup-shaped structures predominantly around the nucleus. Recruitment to autophagic membranes is controlled by MTMR14. Labile microtubules specifically recruit markers of autophagosome formation like WIPI1, whereas mature autophagosomes may bind to stable microtubules
Tissue Location Ubiquitously expressed. Highly expressed in skeletal muscle, heart, testis, pancreas and placenta. Highly expressed in G361, Sk-mel-28, Sk-mel-13, WM852 and WM451 cells Up-regulated in a variety of tumor tissues
Research Areas
Citations (0)

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WD40 repeat proteins are key components of many essentialbiologic functions. They regulate the assembly of multiproteincomplexes by presenting a beta-propeller platform for simultaneousand reversible protein-protein interactions. Members of the WIPIsubfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladedpropeller structure and contain a conserved motif for interactionwith phospholipids (Proikas-Cezanne et al., 2004 [PubMed15602573]).


Chasman, D.I., et al. PLoS Genet. 5 (11), E1000730 (2009) :Proikas-Cezanne, T., et al. FEBS Lett. 581(18):3396-3404(2007)Proikas-Cezanne, T., et al. Oncogene 23(58):9314-9325(2004)Jeffries, T.R., et al. Mol. Biol. Cell 15(6):2652-2663(2004)

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$ 80.00
Cat# BP17541c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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