|Other Names||6-dihydroxyindole-2-carboxylic acid oxidase, DHICA oxidase, 11418-, Catalase B, Glycoprotein 75, Melanoma antigen gp75, Tyrosinase-related protein 1, TRP, TRP-1, TRP1, TYRP1, CAS2, TYRP, TYRRP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CAS2, TYRP, TYRRP|
|Function||Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized.|
|Cellular Location||Melanosome membrane; Single- pass type I membrane protein. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex (By similarity).|
|Tissue Location||Pigment cells.|
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This gene encodes a melanosomal enzyme that belongs to thetyrosinase family and plays an important role in the melaninbiosynthetic pathway. Defects in this gene are the cause of rufousoculocutaneous albinism and oculocutaneous albinism type III.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rausch, M.P., et al. J. Immunol. 185(5):2828-2835(2010)Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :Edwards, M., et al. PLoS Genet. 6 (3), E1000867 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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