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TYRP1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P17643
Clone Names 80722110
Peptide ID 80722110
Additional Information
Gene ID 7306
Other Names 6-dihydroxyindole-2-carboxylic acid oxidase, DHICA oxidase, 11418-, Catalase B, Glycoprotein 75, Melanoma antigen gp75, Tyrosinase-related protein 1, TRP, TRP-1, TRP1, TYRP1, CAS2, TYRP, TYRRP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TYRP1
Synonyms CAS2, TYRP, TYRRP
Function Catalyzes the oxidation of 5,6-dihydroxyindole-2- carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.
Cellular Location Melanosome membrane {ECO:0000250|UniProtKB:P07147}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P07147}. Melanosome {ECO:0000250|UniProtKB:P07147}. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. {ECO:0000250|UniProtKB:P07147}
Tissue Location Pigment cells.
Research Areas
Citations (0)

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Background

This gene encodes a melanosomal enzyme that belongs to thetyrosinase family and plays an important role in the melaninbiosynthetic pathway. Defects in this gene are the cause of rufousoculocutaneous albinism and oculocutaneous albinism type III.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rausch, M.P., et al. J. Immunol. 185(5):2828-2835(2010)Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :Edwards, M., et al. PLoS Genet. 6 (3), E1000867 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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$ 80.00
Cat# BP17543c
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