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PPIE Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UNP9 |
|---|---|
| Clone Names | 100603033 |
| Gene ID | 10450 |
|---|---|
| Other Names | Peptidyl-prolyl cis-trans isomerase E, PPIase E, Cyclophilin E, Cyclophilin-33, Rotamase E, PPIE, CYP33 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PPIE |
|---|---|
| Synonyms | CYP33 {ECO:0000303|PubMed:8977107} |
| Function | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346). Combines RNA-binding and PPIase activities (PubMed:8977107, PubMed:18258190, PubMed:20677832, PubMed:20460131). Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules (PubMed:8977107, PubMed:18258190, PubMed:20460131). Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins (PubMed:8977107, PubMed:18258190, PubMed:20677832, PubMed:20541251). Inhibits KMT2A activity; this requires proline isomerase activity (PubMed:20677832, PubMed:20541251, PubMed:20460131). |
| Cellular Location | Nucleus |
| Tissue Location | Found in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of thepeptidyl-prolyl cis-trans isomerase (PPIase) family. PPIasescatalyze the cis-trans isomerization of proline imidic peptidebonds in oligopeptides and accelerate the folding of proteins. Thisprotein contains a highly conserved cyclophilin (CYP) domain aswell as an RNA-binding domain. It was shown to possess PPIase andprotein folding activities, and it also exhibits RNA-bindingactivity. Alternative splicing results in multiple transcriptvariants. A related pseudogene, which is also located on chromosome1, has been identified.
References
Park, S., et al. Biochemistry 49(31):6576-6586(2010)Hom, R.A., et al. J. Mol. Biol. 400(2):145-154(2010)Wang, Z., et al. Cell 141(7):1183-1194(2010)Naukkarinen, J., et al. PLoS Genet. 6 (6), E1000976 (2010) :Chen, J., et al. Cancer Res. 68(15):6199-6207(2008)
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