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IMPACT Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9P2X3
Clone Names 100603284
Peptide ID 100603284
Additional Information
Gene ID 55364
Other Names Protein IMPACT, Imprinted and ancient gene protein homolog, IMPACT
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1- mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:O55091}.
Tissue Location Widely expressed. Expressed at high level in brain.
Research Areas
Citations (0)

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Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity).


Habibi, D., et al. J. Cell. Physiol. 225(1):196-205(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Pereira, C.M., et al. J. Biol. Chem. 280(31):28316-28323(2005)Okamura, K., et al. Biochem. Biophys. Res. Commun. 329(3):824-830(2005)Okamura, K., et al. DNA Res. 11(6):381-390(2004)

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$ 80.00
Cat# BP17553a
Availability: In Stock
Bulk Size
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