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IMPACT Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9P2X3
Clone Names 100603284
Peptide ID 100603284
Additional Information
Gene ID 55364
Other Names Protein IMPACT, Imprinted and ancient gene protein homolog, IMPACT
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IMPACT
Function Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity). May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis (By similarity). Through its action on GCN2, may also facilitate neuritogenesis (By similarity).
Cellular Location Cytoplasm. Note=May be associated with polysomes.
Tissue Location Widely expressed. Expressed at high level in brain.
Research Areas
Citations (0)

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Background

Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity).

References

Habibi, D., et al. J. Cell. Physiol. 225(1):196-205(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Pereira, C.M., et al. J. Biol. Chem. 280(31):28316-28323(2005)Okamura, K., et al. Biochem. Biophys. Res. Commun. 329(3):824-830(2005)Okamura, K., et al. DNA Res. 11(6):381-390(2004)

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$ 80.00
Cat# BP17553a
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