|Other Names||Protein IMPACT, Imprinted and ancient gene protein homolog, IMPACT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity). May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis (By similarity). Through its action on GCN2, may also facilitate neuritogenesis (By similarity).|
|Cellular Location||Cytoplasm. Note=May be associated with polysomes.|
|Tissue Location||Widely expressed. Expressed at high level in brain.|
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Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity).
Habibi, D., et al. J. Cell. Physiol. 225(1):196-205(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Pereira, C.M., et al. J. Biol. Chem. 280(31):28316-28323(2005)Okamura, K., et al. Biochem. Biophys. Res. Commun. 329(3):824-830(2005)Okamura, K., et al. DNA Res. 11(6):381-390(2004)
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