DUSP6 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q16828 |
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Clone Names | 100430231 |
Gene ID | 1848 |
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Other Names | Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3, MAP kinase phosphatase 3, MKP-3, DUSP6, MKP3, PYST1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DUSP6 |
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Synonyms | MKP3, PYST1 |
Function | Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977). |
Cellular Location | Cytoplasm. |
Tissue Location | Expressed in keratinocytes (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the dualspecificity protein phosphatase subfamily. These phosphatasesinactivate their target kinases by dephosphorylating both thephosphoserine/threonine and phosphotyrosine residues. Theynegatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different membersof the family of dual specificity phosphatases show distinctsubstrate specificities for various MAP kinases, different tissuedistribution and subcellular localization, and different modes ofinducibility of their expression by extracellular stimuli. Thisgene product inactivates ERK2, is expressed in a variety of tissueswith the highest levels in heart and pancreas, and unlike mostother members of this family, is localized in the cytoplasm. Twotranscript variants encoding different isoforms have been found forthis gene.
References
Chiappinelli, K.B., et al. Gynecol. Oncol. 119(1):146-150(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Nunes-Xavier, C.E., et al. J. Biol. Chem. 285(34):26417-26430(2010)Zhang, Z., et al. Carcinogenesis 31(4):577-586(2010)Wang, Z., et al. Mol. Vis. 16, 1696-1704 (2010) :
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