|Other Names||28S ribosomal protein S11, mitochondrial, MRP-S11, S11mt, Cervical cancer proto-oncogene 2 protein, HCC-2, MRPS11, RPMS11|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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Mammalian mitochondrial ribosomal proteins are encoded bynuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of asmall 28S subunit and a large 39S subunit. They have an estimated75% protein to rRNA composition compared to prokaryotic ribosomes,where this ratio is reversed. Another difference between mammalianmitoribosomes and prokaryotic ribosomes is that the latter containa 5S rRNA. Among different species, the proteins comprising themitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequencehomology. This gene encodes a 28S subunit protein that contains ahigh level of sequence similarity with ribosomal protein S11Pfamily members. A pseudogene corresponding to this gene is found onchromosome 20. Sequence analysis identified two transcript variantsthat encode different protein isoforms.
Ishiguchi, H., et al. Int. J. Cancer 111(6):900-909(2004)Zhang, Z., et al. Genomics 81(5):468-480(2003)Kenmochi, N., et al. Genomics 77 (1-2), 65-70 (2001) :Suzuki, T., et al. J. Biol. Chem. 276(35):33181-33195(2001)Cavdar Koc, E., et al. J. Biol. Chem. 276(22):19363-19374(2001)
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