|Other Names||Protein crumbs homolog 3, CRB3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions.|
|Cellular Location||Apical cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells|
|Tissue Location||Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate.|
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This gene encodes a member of the Crumbs family ofproteins. This protein may play a role in epithelial cell polarityand is associated with tight junctions at the apical surface ofepithelial cells. Alternate transcriptional splice variants,encoding different isoforms, have been characterized. [provided byRefSeq].
Pardossi-Piquard, R., et al. Biochemistry 46(48):13704-13710(2007)Fan, S., et al. J. Cell Biol. 178(3):387-398(2007)Fogg, V.C., et al. J. Cell. Sci. 118 (PT 13), 2859-2869 (2005) :Lemmers, C., et al. Mol. Biol. Cell 15(3):1324-1333(2004)Roh, M.H., et al. J. Cell. Sci. 116 (PT 14), 2895-2906 (2003) :
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