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CRB3 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9BUF7
Clone Names 110617201
Additional Information
Gene ID 92359
Other Names Protein crumbs homolog 3, CRB3
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CRB3 (HGNC:20237)
Function Involved in the establishment of cell polarity in mammalian epithelial cells (PubMed:12771187, PubMed:14718572). Regulates the morphogenesis of tight junctions (PubMed:12771187, PubMed:14718572). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity).
Cellular Location Apical cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells.
Tissue Location Preferentially expressed in epithelial tissues (PubMed:14718572). Expressed at high levels in lung, kidney, and colon (PubMed:12527193, PubMed:14718572). Expressed at high levels in retina, colon and mammary glands (PubMed:12527193). Moderately expressed in liver, spleen, pancreas and prostate (PubMed:12527193). Moderately to weakly expressed in the placenta (PubMed:14718572, PubMed:12527193) Weakly expressed in skeletal muscle and small intestine (PubMed:14718572).
Research Areas
Citations (0)
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Background

This gene encodes a member of the Crumbs family ofproteins. This protein may play a role in epithelial cell polarityand is associated with tight junctions at the apical surface ofepithelial cells. Alternate transcriptional splice variants,encoding different isoforms, have been characterized. [provided byRefSeq].

References

Pardossi-Piquard, R., et al. Biochemistry 46(48):13704-13710(2007)Fan, S., et al. J. Cell Biol. 178(3):387-398(2007)Fogg, V.C., et al. J. Cell. Sci. 118 (PT 13), 2859-2869 (2005) :Lemmers, C., et al. Mol. Biol. Cell 15(3):1324-1333(2004)Roh, M.H., et al. J. Cell. Sci. 116 (PT 14), 2895-2906 (2003) :

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$ 277.78
Cat# BP17560c
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